Preventing joint bleeding sequelae

Location: Pacifico

CE: 1

Chair(s)

Johan Blokzijl

Physiotherapist & PhD-student
Center for Benign Haematology, Thrombosis and Haemostasis, Van Creveldkliniek
University Medical Center Utrecht
Cedric Hermans, MD, FRCP, PhD (he/him/his)

Head, Hemophilia Center
Hematology
Cliniques Universitaires Saint-Luc
Brussels, Belgium
Annette von Drygalski, MD. PharmD, RMSK (she/her/hers)

Director, Hemophilia and Thrombosis Treatment Center
Medicine
University of California
La Jolla, United States

Blood induced joint damage: This presentation will focus on the mechanism that causes an intra-articular bleed to lead to hemophilic arthropathy.  The three major processes involved (synovitis, degeneration of the cartilage and damage to the underlying bone) will be clarified and in addition changes over time will be considered.
Current hemostasis management: Prevention of spontaneous joint and muscle bleeds, including subclinical bleeds, for all patients with a severe phenotype represents the current ambition for the treatment of haemophilia. This presentation will assess the extent to which available and future therapies, both substitutive and non-substitutive, can achieve this goal, especially for subclinical bleeds in patients with haemophilia A and B.
Therapy for blood induced joint damage: Blood-induced joint damage affects bone, cartilage, and soft tissue structures. However, the extent, severity, speed, and potential reversibility varies between individuals. Rapid diagnostic assessment tools, such as point-of-care (POC) ultrasound, followed by innovative individualized management paradigms to prevent progression will become critical. This presentation will discuss various manifestations of joint damage in response to bleeding, and the use of POC ultrasound and other imaging modalities to guide management.

15:30 - 15:31 ART

Chair
Chair: Adolfo Llinas, MD – Fundacion Santa Fe de Bogota
15:31 - 15:45 ART

Blood induced joint damage
Speaker: Johan Blokzijl – University Medical Center Utrecht
15:45 - 16:00 ART

Current hemostasis management
Speaker: Cedric Hermans, MD, FRCP, PhD (he/him/his) – Cliniques Universitaires Saint-Luc
16:00 - 16:15 ART

Therapy for blood induced joint damage
Speaker: Annette von Drygalski, MD. PharmD, RMSK (she/her/hers) – University of California
16:15 - 16:30 ART

Discussion
Chair: Adolfo Llinas, MD – Fundacion Santa Fe de Bogota