Lab: Point of care

Location: Atlantico

CE: 1

Chair(s)

Emna Gouider, MD

Chief
Biological Hematology Department
Aziza Othmana Hospital- University Tunis El Mana
Tunis, Tunisia

Speaker(s)

David Bark, Jr., PhD (he/him/his)

Assistant Professor
Pediatric Hematology and Oncology
Washington University in St. Louis
St. Louis, United States
Assad Haffar

Medical & Humanitarian Aid Director
World Federation of Hemophilia
Shrimati Shetty, PhD

Director, Laboratory Hematology & Clinical Research
Advanced Center for Oncology, Hematology & Rare Disorders
K.J.Somaiya Hospital & Research Center
Mumbai, India
Waander van Heerde, PhD (he/him/his)

Academic Clinical Assistant, Hematology
Hematology
Radboudumc, HTC-NEM
Nijmegen, Netherlands

Learning Objectives:

What is a good point of care test?: Diagnosis of inherited bleeding disorders is quite challenging particularly in large countries or in countries with limited resources. It is quite difficult to mobilize suspected individuals who live in remote areas for testing in advanced laboratories. It is quite important to start testing in the field using a Point of Care that is easy to operate with minimum training, gives sensitive and reliable information, uses whole blood and not expensive. The presentation will highlight all these aspects with some practical examples.
Examples of POC technology
A simple point of care (POC) test for diagnosis of moderate to severe hemophilia A and von Willebrand disease (VWD): A POC has been developed and validated for diagnosis of moderate to severe hemophilia A and VWD. The sensitivity and specificity of the factor VIII-POC has been found to be 94.48% and 98.71% respectively, while that of VWF-POC is 98.14% and 99.18% respectively. The kit has high utility in places where the diagnostic facilities for these two disorders are not easily available.
Making point of care microfluidics accessible for detecting hemophilia and von Willebrand disease: Over decades, microfluidics have emerged as a point of care tool for many different diseases. However, like many diagnostics, these devices have required sophisticated equipment, electricity, and are generally difficult to use outside of a lab environment. We are developing a microfluidic device that, instead, follows an ASSURED (Affordable, Sensitive, Specific, User-friendly, Rapid & Robust, Equipment free, and Deliverable) criteria to detect hemophilia and von Willebrand disease. Here, we will discuss how microfluidics have been used in these diseases, and how we are translating this work into a device that meets the ASSURED criteria for use in remote areas.

Presentations:

16:45 - 16:46 ART

Chair
Chair: Emna Gouider, MD – Aziza Othmana Hospital- University Tunis El Mana
16:46 - 16:57 ART

What is a good point of care test?
Speaker: Assad Haffar – World Federation of Hemophilia
16:57 - 17:09 ART

Examples of POC technology
Speaker: Waander van Heerde, PhD (he/him/his) – Radboudumc, HTC-NEM
17:09 - 17:21 ART

A simple point of care (POC) test for diagnosis of moderate to severe hemophilia A and von Willebrand disease (VWD)
Speaker: Shrimati Shetty, PhD – K.J.Somaiya Hospital & Research Center
17:21 - 17:33 ART

Making point of care microfluidics accessible for detecting hemophilia and von Willebrand disease
Speaker: David L. Bark, Jr., PhD (he/him/his) – Washington University in St. Louis
17:33 - 17:45 ART

Discussion
Chair: Emna Gouider, MD – Aziza Othmana Hospital- University Tunis El Mana